Protein Details: Potassium voltage-gated channel subfamily H member 8

Protein ID

ICDB_Pro_0645

Protein Name

Potassium voltage-gated channel subfamily H member 8

Gene Name

Kcnh8

Organism

Mus musculus (Mouse)

Length

1102 amino acids

AlphaFoldDB

AF-P59111-F1-model_v4.pdb

Function

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating; outward rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly (By similarity)

Sequence

MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKSCSCKFLFGVETNEQLMLQIEKSLEEKVEFKGEIMFYKKNGAPFWCLLDIVPIKNEKGDVVLFLASFKDITDTKVKITSEDKKEDRTKGRSRAGSHFDSARRRSRAVLYHISGHLQRREKNKLKINNNVFVDKPAFPEYKASDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNEDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLGLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSTVSQAEPKGNGSINKRLPSIVEDEEEEEVEEEETTSLSPIYTRGSSVSHSKKTGSNKTYLGLSLKQLASGTVPFHSPIRVSSANSPKTKQEADPPNHGRKKEKNLKVQLSSLGSAGTPELSPRIVDGIEDGNSNEETQTFDFGSEQIRPEPRISPPLAESEIGAAFLFIKAEETKQQINKLNSEVTTLTQEVSQLGRDMRSIMQLLENILSPQQPSQFCSLHPTPMCPSRESLQTRVSWSAHQPCLHLQAGGAHLYHGNVASGIWSVDPSLVGSSPQRTEAHEQNPADSELHHSPNLDYSPSHCQVIQEGHLQFLRCISPHSDTTLTPLQSISATLSSSVCSSSETSLHLVLPSRSEEGSITHGPVSSFSLENLPGSWDREQMMSASSERLENFPVEVVTSTADVKDSKAINV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

551..668

Disease

Location

DOI ID

10.1371/journal.pbio.1000112; 10.1126/science.1112014; 10.1101/gr.2596504

RefSeq

NP_001026981.2